1Ahmad Saihu | 2Ari Suwondo | 3Yuliani Setyaningsih
Metal casting workers are workers at risk of exposure to heavy metals cadmium. Clinical and laboratory evidence suggests that cadmium exposure is highly toxic by inhalation and may lead to decreased renal function. The purpose of this study was to determine the association of cadmium content in blood to serum creatinine and the estimated glomerular filtration rate. This research uses analytic observation method with Cross Setional approach. The sample size in this research is 30 samples taken from Ceper foundry industry of Klaten Regency, Central Java. Atomic Absorbtion Spectophotometer (AAS) is used to measure blood levels of cadmium, spectrophotometers to measure serum creatinine levels, and to calculate glomerular filtration rate estimation values using Cockcroft and Gault formulas. Data analysis using Chi Square and logistic regression. Results from the study showed an association between cadmium in blood (P-Value = 0.001) against serum keratinin levels. and there was no correlation between cadmium content in blood (P-Value = 0, 576) against glomerular filtration score estimation value. Thus, cadmium levels in the blood are associated with serum creatinine levels, checkup madical needs to be done to determine the health conditions of the workers, as well as to reduce exposure to cadmium by modifying workplace ventilation and using personal protective equipment.
Keywords: Cadmium, serum creatinine, Glomerular filtration rate