Arief Nur Rachmanto1 | Hantoro Ishardyanto2 | Iskandar Ali2 | Rosy Setiawati3
1,2,3Resident of Surgery Department, Faculty of Medicine Universitas Airlangga
Dr. Soetomo General Hospital Surabaya
Abstract
Breast cancer is one of the most prevalent cancer in Indonesia and the most prevalent cancer in women. Patients in Dr. Soetomo Hospital Surabaya generally comes in an advanced stage condition (locally advanced breast cancer). 52% of the patients with breast cancer in Dr. Soetomo hospital did not respond well to chemotherapy treatment. This is related to low levels of vitamin D in the blood, which decreases the therapeutic response of breast cancer. The design of this research is a prospective cohort of patients with locally advanced breast cancer. Patients were examined for vitamin D levels and tumor mass size 1 day before the chemotherapy regiment was carried out and after 3 of CAF chemotherapy regimens were administered, an evaluation of the therapeutic response in patients was done by comparing tumor mass size before and after chemotherapy with ultrasound. There were 30 patients evaluated. 17 people (56.7%) with low level of vitamin D and 13 (43.3%) with normal level of vitamin D. The therapeutic response was obtained as follow, 13 people (43.3%) with partial response, 16 people (53.3%) with stable disease, and 1 person (3.3%) with progressive disease. Statistical tests proved a significant relationship between levels of vitamin D with chemotherapy response in patients with locally advanced breast cancer (p = 0.026). There is a relationship between levels of vitamin D in blood with the size of the tumor, based on ultrasound examination, as a response to neoadjuvant chemotherapy of CAF in postmenopausal women with locally advanced breast cancer in Dr. Soetomo General Hospital Surabaya
Keywords: Locally Advanced Breast Cancer, Vitamin D, Chemotherapy Response, Breast Cancer
