Lintong Darianto S. Damanik1 | Hantoro Ishardyanto2
1Resident of Surgery, Faculty of Medicine Universitas Airlangga /Dr. Soetomo General Hospital Surabaya
2Staff of the Department of Surgery, Oncology Division, Faculty of Medicine Universitas Airlangga /Dr. Soetomo General Hospital Surabaya
Breast cancer is the most common cancer in women and is the highest cause of death. As many as 2.1 million women in the world suffer from breast cancer each year. Data in Dr. Soetomo Hospital show patient cancer breast came with a case of locally advanced breast cancer as much as 47% and 52% of the cases do not respond well to neoadjuvant chemotherapy. The inflammatory state and nutritional status of the patient play a role in the therapeutic success of the patient. The presence of inflammation and the status of the nutrients are poorly related to the response of clinically against chemotherapy are low. The state of inflammation and status of nutrition it can be seen from the ratio between CRP with albumin. The research was a prospective cohort design, on patients with locally advanced breast cancer. Patients performed the examination levels of albumin and CRP before the chemotherapy is given and carried out the measurement of the mass of the tumor with a physical examination. Then the patient underwent neoadjuvant chemotherapy with the CAF regimen for 3 cycles and was examined for CRP, albumin, and tumor size again. Then evaluated for response to therapy. In this study, a total of 35 patients were obtained with 12 people (34.3%) with a low CRP / Albumin ratio and 23 people (65.7%) with a high CRP / Albumin ratio. From the clinical response found 0 people (0%) with progressive disease, 7 people (20%) with stable disease, 23 people (65.7%) with partial response and 5 people (14.3%) with complete response. Statistical test results showed that there was a significant relationship between CRP / Albumin ratio with chemotherapy response (p = 0.004). It was obtained a significant relationship between the increased ratio of CRP / Albumin with a decrease in response to neoadjuvant chemotherapy of CAF in patients with Locally Advanced Breast Cancer.
Keywords: Locally Advanced Breast Cancer, CRP, Albumin, CRP/Albumin Ratio, Response to Chemotherapy, Breast Cancer