I Made Mahandhika1 | Maryono Dwi Wibowo2 | Dwi Hari Susilo3 Abstract Multinodular goiter is an enlargement of the thyroid gland with multiple nodules histologically in which the thyroid gland follicles undergo morphological and functional changes, these changes will affect the patient’s life, including the physical changes, mental, functional, and social. Operation is one of the choices of goiter management. After the therapy is done, the attention will change to how is the quality of life of the patients after therapy. The purpose of this studiy to determine the effect of thyroidectomy surgery on the quality of life of the health aspects of nontoxic multinodular goiter patients aged 21 – 45 years before and after surgery. This study used primary data and secondary data from medical records of an outpatient clinic in post-operative patients. The study design was a prospective cohort method. The sample used was patients who have been diagnosed with non-toxic multinodular goiter who agreed to perform thyroidectomy surgery that met the study inclusion and exclusion criteria. This study showed that the quality of life in patients before surgery of 19 people (63%) had a poor quality of life (questionnaire value 0-60) and 11 people (37%) had a good quality of life (questionnaire value> 60). Then after surgery, the patient was assessed for quality of life, and the data obtained was 7 people (23.3%) had a poor quality of life and 23 people (76.3%) had a good quality of life. Then a statistical test was performed and it was found that there was a statistically significant difference between the quality of life of nontoxic multimode goiter patients before and after thyroidectomy surgery with a value (p = 0.021). There was a statistically significant difference between the quality of life of nontoxic multimode goiter patients before and after thyroidectomy with a value (95% CI; p = 0.021). Keywords: Multinodular goiter, Thyroidectomy, quality of life. |