Relationship of Vitamin D Serum Levels with Recurrence of Breast Cancer in Premenopausal Patients with Locally Advanced Hormonal Dependent Breast Cancer with Tamoxiven Therapy in Dr. Soetomo General Hospital

Anike Natalina Sirait¹ | Hantoro Ishardyanto² | Eddy Herman Tanggo³

Abstract

Breast cancer is a type of cancer that often occurs in women. Many of the cases are found in the advanced stage. Approximately 40% of patients with breast cancer experienced a recurrence. Currently one of the treatments on breast cancer with positive estrogen receptor is with Tamoxifen. Tamoxifen has a role as an anti-proliferation in cancer cells. From several studies, vitamin D has anticancer effects, one of which is anti-proliferation. The purpose of this study to know the correlation between levels of vitamin D in the proliferation of cancer cells which are seen from the number of recurrences in locally advanced breast cancer. This research was analytic observational in a cross sectional design. Research samples were all premenopausal patients with locally advanced breast cancer who underwent hormonal therapy of Tamoxifen in Dr. Soetomo General Hospital of Surabaya from 2017 to 2019. Data on vitamin D levels were obtained from the patient’s blood tests and data of recurrence were obtained through medical records. The total subjects of this research were 30 people, with the proportion of subjects with vitamin D deficiency were 25 people (83%) and normal vitamin D were 5 people (17%). Recurrence events were found in 15 people (50%), in 15 people (50%) recurrences did not occur. Data were analyzed with chi-square analysis and found significant differences between the two groups of vitamin D deficiency and normal vitamin D to the recurrence of locally advanced breast cancer (p = 0.014). There is a relationship between vitamin D levels and the level of recurrence in premenopausal female patients with locally advanced hormonal-dependent breast cancer that is receiving tamoxifen therapy.

Keywords:  Breast cancer, vitamin D, LABC Dependent Hormonal, Tamoxifen

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