Daniel Doli Haholongan1 | Iskandar Ali2 | Eddy Herman Tanggo2
1Resident of Surgery, Faculty of Medicine Universitas Airlangga /Dr. Soetomo General Hospital Surabaya
2Staff of the Department of Surgery, Oncology Division, Faculty of Medicine Universitas Airlangga /Dr. Soetomo General Hospital Surabaya
Abstract
Breast cancer is one of most major cause of death in women. One of the forms of breast cancer that has poor prognosis is triple negative breast cancer (TNBC). TNBC occurs in 10-20% of breast cancer, with high number of relapse/recurrence and metastasis. In some earlier research, it was found that the number of TNBC was higher in patients with obesity. Therefore, obesity is associated with poor prognosis in patients with breast cancer. This research wants to study the relationship of obesity with recurrence in TNBC patients. This research is a prospective cohort research in patients with triple negative breast cancer. Research was carried out by recording patients with TNBC and measurement of the degree of obesity by calculating the body mass index (BMI). Patients was followed-up for 6 months after surgery to monitor if there is any recurrence. In this research, it was obtained a total of patients of 58, 33 people (56.9%) with normal BMI and 25 people (43.1%) with obesity. From the terms of recurrence, it was obtained 30 people (51.7%) did not experience recurrence and 28 people (48.3%) experienced a recurrence. Statistical tests proved that there is significant relationship between obesity with the incidence of recurrence (p = 0.002) with an odds ratio (OR) of 6.29. Increased BMI increase the incidence of recurrence cases in patients with Triple Negative Breast Cancer
Keywords: Triple Negative Breast Cancer, Recurrence, Obesity, Cancer Breast
