Authors: Sainal Edi Kamal1, Zulfiah2, Rina Asrina3, Muh. Farid Hasyim4, Agus Dwi Jayanti5
1,2,3,4 Sandi Karsa Pharmaceutical Academy of Makassar, Indonesia
5Yamasi Pharmaceutical Academy of Makassar, Indonesia
Abstract
The antipyretic effects test of ethanol extracts of green chiretta herbs on male mice has been conducted with the purpose of obtaining scientific data as traditional medicine. This test used 18 male mice that were divided into 6 groups, 4 groups were given extract orally as much as 1ml/30grams body weight of male mice, with a concentration of 1% w/v, 2% w/v, 4% w/v, and 8% w/v as well as the comparison of paracetamol suspension 0.02% w/v and Na.CMC control 1% w/v. The male mice were fasted before the treatment, and then 10% peptone solution is injected intraperitoneally. The temperature is measured again after the administration of the green chiretta ethanol extract paracetamol suspension, and Na.CMC 1% w/v. The research results showed that all of the concentrations of green chiretta herbs ethanol extract can lower the body temperature of male mice. The drop in temperature for the green chiretta herbs ethanol extract concentration of 8% w/v shows the effect of temperature decrease is not significantly different from paracetamol suspension of 0.02% w/v at the level of 5% (α = 0.05).
Keywords: Green Chiretta Herbs, Antipyretic, Male Mice