Lethal Dose 50 (LD 50) Extract Ethanol Meat Oyster

^Author: Ruslan Hasani¹, Budiono², Naharia Laubo^3
1&3Department of Nursing, Health Polytechnic of Ministry of Health in Makassar, Indonesia
²Department of Nursing, Health Polytechnic of Ministry of Health in Malang, Indonesia

Abstract

The aim of this research was to know Lethal Dose 50 ethanol extract of oyster meat, to know the weight change in mice after giving oyster ethanol extract for seven days. This research method was true experimental by using time series control group design. The test object was 45 male (Mus musculus) mice. They were divided into 9 groups: one control group, and eight treatment groups. Observation of dead animals was done for up to seven days. The results of this study were the ethanol extract of oyster meat did not cause death in animal experiments.Treatment groups that gained weight from baseline body weight were 8%, 12%, 14%, and 16%, and the weight-loss group was in the 32%. The conclusion of this study was LD⁵⁰ ethanol extract of oyster meat was pseudo because it did not cause death in animal try to the highest dose limit of 10.64 g / kgbw. The best weight change was achieved in the 8% mice group.

Keywords: Oyster, ethanol extract, LD⁵⁰, mice

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