Authors: 1Dwi Susiloningrum-Faculty of Pharmacy, 2Ahmad Fuad Hafid-Universitas Airlangga, 3Aty Widyawaruyanti-Surabaya 60286 Indonesia
E-mail: susiloningrumdwi@yahoo.com
Abstract
Hepatitis is a health problem in the world that can cause the deaths of millions ofpeople worldwide, but there is no vaccine available for HCV. Currently, pegylated interferon (PegIFN-α) and ribavirin combination therapy are used as standard therapy for chronic HCV infection. Treatment with a combination of standard interferon and Ribavirin has limited benefits because it can lead to resistance during long-term treatment and various side effects. Medicinal plants are one of the potential therapeutic sources for hepatitis drugs. In plants that contain chemical compounds such as flavonoids, terpenoids, lignans, sulfides, polyphenols, coumarin, saponins, furil compounds, alkaloids, proteins and peptides tend to inhibit replication cycles of different types of DNA or RNA. The profile of plant metabolites in one species may be different. This can be due to internal and external factors, these different factors can cause different activities. Family rutaceae is a plant that has been widely reported to have activity as an anti-viral hepatitis C. Objective: explain the activity of family rutaceae as antiviral hepatitis C.
Keyword: Antivirus Hepatitis C, Family Rutaceae, Profil Metabolit
