Synthesis and Characterization of 2-Benzamido-N-Benzoylbenzamide

^Authors: Ani Riani Hasana^1, Siswandono², Marcellino Rudyanto²

Department of Pharmaceutical Chemistry,

Faculty of Pharmacy, Universitas Airlangga, Indonesia

E-mail : anirianihasana@gmail.com

Abstract

Anthranilamide or 2-aminobenzamide is imide form of anthranilic acid. Anthranilamide derivatives is used for analgesic, antipyretic, anti-inflammatory, antimicrobial, antiangiogenic, and anticoagulant activity. 2-benzamido-N-benzoylbenzamide was obtained Schotten-Baumann reaction via the acylation of anthranilamide with benzoyl chloride. The structure of the 2-benzamido-N-benzoylbenzamide was purified test by Thin Layer Chromatography (TLC) and melting point range test; confirmed by UV-Vis Spectrophotometry, FT-IR and ¹H-NMR. Yield 71%.

KEYWORDS : Anthranilamide, Acylation, Benzoyl Chloride, Schotten-Baumann Reaction

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