Causes of Erythropoietin Hyporesponsiveness in Chronic Kidney Disease

^Authors: Dhunik Lukitasari¹, Suharjono²

Master of Clinical Pharmacy,

Faculty of Pharmacy, Airlangga University,

Surabaya, Indonesia

Abstract

Based on reports from the K/DOQI (2006), note that approximately 5-10% of patients of chronic kidney disease (CKD) has a low response (hyporesponsiveness) against erythropoietin. Effects of erythropoietin hyporesponsiveness such will cause the risk of cardiovascular disease and mortality being higher. The most common cause of erythropoietin hyporesponsiveness is absolute or functional iron deficiency. In addition, there are several other factors that can also cause erythropoietin hyporesponsiveness, such as chronic inflammation, malnutrition inflammation complex syndrome (MICS), the inadequate dialysis, uremia, hyperparathyroidism, aluminium intoxication, blood loss, malignancy, and diseases of the bone marrow disorders. Identification of the related causes of erythropoietin hyporesponsiveness need to know in order to determine the next steps in the management of anemia.

Keyword : Erythropoietin Hyporesponsiveness, Chronic Kidney Disease, Anemia.

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