Authors: Rizal, Diah Sri E, Devi Oktafia, Didik Hasmono
Department of Clinical Pharmacy, Faculty of Pharmacy,
Airlangga University, Surabaya,East Java, Indonesia
email: rizal.alzanzhy@gmail.com
Abstract
According to WHO data in 2016, about 50 million people hsve epilepsy worldwide, which make epilepsy one of the most common neurological diseases. Antiepileptic drugs (AED) therapy are used in the long term. Its use was reported associate with the decrease bone mineral density (BMD), calcium serum, levels of 25 (OH) D3, the increase parathyroid hormone (PTH), changes in bone turnover and the increase risk of fracture. Phenytoin, carbamazepine and valproic acid are widely used AEDs in the world. This review investigated research data related to effects of antiepileptic drugs on the bone using BioMed Central, Pubmed and Google Schoolar database. We aimed to provide a new understanding of the effects of antiepileptic drugs (phenytoin, carbamazepine, valproate) on the increase risk of fracture.
Keywords: Epilepsy, Antiepileptic, Fracture
