Ceftriaxone and DHF Induced Hepatocellular Enzyme Elevation in Pediatric: Focus on Management

^Authors: widiyanti Afifah¹, Ana Nurlaili Hidayat², Nurul Ma’rifah³, Retno Nurhayati

^{1,2 ,3}Master of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University,

⁴Aisyiyah Bojonegoro Hospital, Airlangga University,

Dharmawangsa Dalam, 60286, Surabaya, Indonesia

Email: widiyantiafifah@yahoo.com

Abstract

There is no spesific treatment for patient with hepatocellular enzyme elevation  caused by dengue and/ or cefriaxone. We report a child with transaminitis caused by dengue and/ or cefriaxone. A 9-months-old girl was diagnosed dengue haemorrhagic fever grade III with transaminitis. After administration of intravenous N-acetylcysteine and Ursodeoxycholic acid, a rapid decrease in liver transaminase was observed followed by clinical improvement.

Keyword:  N-acetylcysteine, ursodeoxycholic, dengue, liver injury, paediatric

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