Authors: Nurul Ma’rifah1*, Ana Nurlaili Hidayah2, Widyanti Afifah3, Didik Hasmono4
Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University.
Jalan Dharmawangsa Dalam, 60286 Surabaya, Indonesia
*Corresponding Author E-mail : nurul.pharm@gmail.com
Abstract
Bone is a special connective tissue made up of several cell types surrounded by a collagen matrix, called osteoid, upon which are deposited minerals, particularly the crystals of calcium and phosphate known as hydroxyapatite. There are three types of bone cells that affect the formation and damage of the bones of osteoblasts, osteocytes and osteoclasts. Throughout life, bone is constantly remodeled by the osteoblasts and osteoclasts working together. Osteoclasts resorb old bone, and then osteoblasts move into the area and lay down new matrix, which becomes mineralized. There are several drugs that can be used for osteoporosis therapy (1) Bisphosphonate, (2) Denosumab, (3) Calcium and Vitamin D, (4) Parathyroid hormone, (5) Calcitonin, (7) Hormone replacement therapy (HRT).
Keywords: Osteoporosis, bone, biopharmaceutical aspect
