Nanostructure Lipid carrier (NLC) as a Skin Delivery System

^Authors: Christin Beama ^1,2*, Tristiana Erawati¹, Widji Soerarti²

Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University.

Jalan Dharmawangsa Dalam, 60286 Surabaya, Indonesia

*Corresponding Author E-mail:ithien.beama3@gmail.com

Abstract

Nanoparticles are one part of nanotechnology that is widely developed on Nano medicine and Nanodermatology. Nanomaterial is a system that has sizes ranging from 1-1000 nm (or 10^-9-10^-7 m). Besides being used for drug delivery, nanoparticles are now also widely used in cosmetic preparations to enhance the performance of active ingredients, protect active ingredients from degradation, alert local action, and prevent active ingredients from entering the bloodstream. Nanoparticles used in cosmetic dosage formulations include Nano-emulsion, Nano-crystal, micelles, polymeric Nano-capsules, noisome, liposomes, nanostructured lipid carriers, solid lipid nanoparticles. Nano Lipid Carrier (NLC) which is the second generation of Solid Lipid Nano particle (SLN) delivery system. NLC consists of a certain amount of lipid matrix and liquid lipids, providing enough space to accommodate drug molecules and consequently enhancing drug trapping capacity, preventing drug release, improving drug stability and increasing flexibility to modulate drug release.

Keywords: Nanoparticle, NLC, Matrix Lipid

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