Authors: Dicka Indo Putri Priyono1, Bambang Wirjatmadi2, Merryana Adriani3
1Master Student at Faculty of Public Health, Airlangga University, Indonesia
2&3Lecturer at Faculty of Public Health, Airlangga University, Indonesia
Abstract
Stevia Sugar is a natural sweetener, made from Stevia rebaudiana Bertoni leaves, that is low in calories and safe to be consumed by people with diabetes mellitus and is believed to be able to reduce blood glucose level by increasing insulin production and its sensitivity. The purpose of this study was to determine the effect of stevia sugar on blood glucose and insulin resistance in alloxan-induced male wistar rats. This research was conducted using a randomized design with Pre-Post Test with Control Group Design. Independent variable was stevia sugar, while the dependent variable were blood glucose and insulin resistance which were measured using HOMA-IR index. Subjects of this study were 25 male wistar rats divided randomly into 5 groups. The result was analyzed using Wilcoxon test (p <0.05) to see the difference of pre and post fasting blood glucose (FBG) levels, Kruskal-Wallis test (p <0.05) followed by Mann-Whitney test (p <0,05) to observe the difference of FBG levels between control and treatment groups, then continued by linear regression of dummy variable to see the most effective dose. Statistic analysis result showed that there was a difference of pre and post FBG levels (p <0,005), stevia sugar effectively decreased blood glucose level in treatment group (p = 0,009), positive control group significantly different from group P1 (stevia 2, 5 mg), P2 (stevia 3.75 mg) and P3 (stevia 5 mg). 3.75 mg stevia sugar was the most effective dose to reduce FBG levels by 20,900 mg / dl.
Keywords : Stevia Sugar, Blood Glucose Levels, Alloxan
