Authors: Hasyim As’ariˡ, Asnani², Dewi Mutmainnah Mahartini³
1&2Health Polytechnic of Ministry of Health in Surabaya, Indonesia
3Nursing Academy of Gresik Regency, Indonesia
Abstract
Hypercholesterolemia plays a role in the etiology of atherosclerosis that contributes in cases of coronary heart disease which is the leading cause of death worldwide. Stress, smoking, and consumption of a high cholesterol diet resulted in an increase in serum LDL. Modification of diet and management with hypolipidemic drugs including sourced from herbs one of which is Garcinia mangostana L. containing mangosteen will affect the decrease in serum LDL. The research design of posttest control group design between independent variables Garcinia mangostana L. rind extract with variable dependent serum LDL level. Types of research was the laboratory experimental studies. The population was the male white rat (Ratus norvegicus) 3-4 weeks old with weight 100-200 gram. Hypercholesterolemia was in male white rats with MDLT induction (high-fat diet foods). The data collection of measuring LDL serum level used an enzymatic method with spectrophotometer. The data analysis of this research used the Analysis of Variance (Anova). The effects of Garcinia mangostana L. rind extract on LDL levels in hypercholesterolemic white rats in experiments grouped to 7 consisted of a negative control group, a positive control group and a treatment group with 4 doses of 50, 150, 250 and 350 mg / kgBW. Serum LDL examination was performed on day 8 to see hypercholesterolemia and day 22 to see the effect of rind-enhancing Garcinia mangostana L on decreased serum LDL levels. The result of observation showed that a mangosteen rind extract Garcinia mangostana L on all given doses caused decreasing a LDL serum level significantly.
Keywords: Garcinia mangostana L, LDL, Hypercholesterolemia
