Saktya Yudha Ardhi Utama1, I Ketut Sudiana2, Kristiawati3
1Master of Nursing Study Program, Faculty of Nursing Universitas Airlangga
2Department of Anatomic Pathology, Faculty of Medicine Universitas Airlangga
3Department of Maternity and Pediatric Nursing, Faculty of Nursing Universitas Airlangga
Abstract
Introduction: Thrombocytopenia is a condition of platelet counts below 150,000/mm3, this may cause bleeding which, if not handled properly, may lead to death. Some actions that can be done to overcome thrombocytopenia, one of which is with papaya leaf. This study aims to analyze the effect of giving papaya leaf extract to increased count and activity of platelets. Methods: This research design uses true experimental with design of post-test only control group design. The sample in this study were 30 male mice (Mus musculus) divided into five groups. The first group as the negative control group (CMC Na 0.5%), the second group as the positive control (CMC Na 0.5%), the third group was given ethanol 96% extract papaya leaf dose 0.5g/kgBW, the fourth group was given ethanol 96% extract papaya leaf dose 1g/kgBW, the fifth group was given ethanol 96% extract papaya leaf dose 2g/kgBW. Data collection using measurement sheet of platelet, bleeding time, clotting time and blood serotonin which were analyzed by MANOVA test. Result: The results of this study showed that platelet variable obtained p<0.0001 the highest average between treatment groups that is treatment group which given dose of 2g/kgBW (2±0,1). In the bleeding time variables p<0.0001 the fastest mean time occur between treatment groups that is treatment group with dose 2g/kgBW (2.74±0.14). In clotting time variables p<0.0001 the fastest mean time occur between treatment group that is treatment group with dose 2g/kgBW (2,24±0,03). On serotonin blood variable p<0.0001 the highest mean is between treatment group that is treatment group which given dose of 2g/kgBW (48,90±3,80). This result shows that there are significant differences between every groups. Discussion: The conclusion of this research is giving papaya leaf extract can increase the count and activity of platelets views of bleeding time, clotting time and blood serotonin
Key Words: papaya leaf; platelet; bleeding time; clotting time; serotonin blood.
